The difference was consistent across subgroups with the exception of Asian people, who showed no difference in mortality between highest and lowest quartiles. The highest quartile of eHSBV (range 4.53-9.86 centipoise ) had significant excess mortality compared with lowest quartile in the 3.01-4.00 cP range (adjusted HR 1.53, 95% CI 1.27-1.84). Those in the highest quartile of eHSBV were more likely to be men, of Black or Hispanic race or ethnicity, have a history of diabetes, and require oxygen support at the time of presentation. Participants with higher eHSBV tended to have higher inflammatory markers at baseline. WBV is largely determined by hematocrit, plasma viscosity, erythrocyte aggregation, and erythrocyte deformability.ĬOVID-19 patients included in the study had been hospitalized at some point from early 2020 to late 2021. Study authors noted that whole blood viscosity (WBV) is a validated measure of blood rheology and established predictor of cardiovascular risk. Rosenson's observational study included 5,621 COVID-19 patients hospitalized across six hospitals in the Mount Sinai Health System. However, those trials did not incorporate blood viscosity as a factor. In the large platform trials, therapeutic-dose heparin improved survival for hospitalized COVID-19 patients outside the ICU but not in the ICU. "We are currently investigating the effects of therapeutic heparin to reduce the risk of complications during acute COVID-19 infections, which may greatly benefit those with high blood viscosity," he added. Results can help determine the best treatment course for at-risk patients and help improve outcomes," said Rosenson in a press release. "This study demonstrates the importance of checking for blood viscosity in COVID-19 patients early in hospital admission, which is easily obtained through routine lab work. Study results supported a link between hyperviscosity and the immune-mediated thrombosis of acute COVID-19 illness.
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